Daniil Medvedev's title defense at the Rome Open ended prematurely on Tuesday as he was knocked out in the last-16 stage by Tommy Paul. The world number four and second seed was defeated 6-1, 6-4 by the American, marking Paul's first victory over Medvedev. Medvedev expressed his disappointment, admitting he needed to be mentally stronger during the match.

Paul will advance to his first Masters 1000 quarter-final on clay, where he will face Hubert Hurkacz, who earlier eliminated Rafael Nadal. Paul credited his pre-clay season training for his improved performance and enjoyment on the surface.

The Rome Open has seen numerous upsets, with top-ranked players like Novak Djokovic, Jannik Sinner, and Carlos Alcaraz either withdrawing or being eliminated early. Other high-profile players like Holger Rune, Andrey Rublev, and Felix Auger-Aliassime have also been knocked out.

Alexander Zverev, ranked fifth in the world, advanced to the quarter-finals by defeating Nuno Borges and will play Taylor Fritz next. Stefanos Tsitsipas, the reigning Monte Carlo champion, also moved into the last eight after a dominant win over Alex de Minaur and will face Nicolas Jarry.

On the women's side, world number one Iga Swiatek continued her dominant run, advancing to the semi-finals with a 6-1, 6-3 victory over Madison Keys. Swiatek, a two-time Rome champion, will next face third seed Coco Gauff, who defeated Zheng Qinwen. Swiatek aims to defend her French Open title later this month and could become the first woman since Serena Williams in 2013 to win both Madrid and Rome in the same season.

Alejandro Tabilo's remarkable journey continued as he reached his first Masters 1000 quarter-final by defeating Karen Khachanov in a thrilling match. Tabilo, who previously stunned Novak Djokovic, will next play China's Zhang Zhizhen. Tabilo described reaching the quarter-finals as an "unreal feeling" and highlighted the need to stay focused and refreshed.